
"Life is the only game in which the object of the game is to learn the rules." This quote emphasizes the complexity of the human body. When buying a new piece of equipment, a manual or instruction booklet usually accompanies it. The human body however, is an extremely complex machine but does not come with a manual. Ross Pelton (co-author of Drug-Induced Nutrient Depletion Handbook) believes that many people do not begin to understand how their body works until something does not work right, or begins to break down. When the body "breaks down", drugs are often prescribed to help with the condition. Drugs can however, alter the taste and smell of foods, which may change a person's appetite and/or food preferences. Many drugs may decrease the absorption or increase the excretion of certain nutrients. Some drugs may decrease the action of enzymes. The following groups of drugs are listed with the nutrients that they may deplete from the body. If you are taking one of these drugs, you may want to speak to your physician about the possibility of a nutrient depletion if you have not already done so.
| Antibiotics | Nutrients that they may affect |
| Isoniazid | Vitamin B6, Vitamin D, Niacin |
| Ethambutol | Zinc, Copper |
| Neomycin | Vitamin A, Vitamin B12, Iron |
| Rifampicin | Vitamin D |
| Tetracyclines | Calcium, Iron, Magnesium |
| Trimethoprim | Folic Acid |
| Anticonvulsants | |
| Biguanides |
Calcium, Folic Acid,Vitamin D |
| Anti-inflammatory Drugs | |
| Corticosteroids | Calcium, Vitamin D, Potassium, Zinc, Magnesium, Selenium, Vitamin C, Folic Acid, Selenium |
| Salicylates | Vitamin C, Folic Acid, Iron, Sodium, Potassium |
| Sulfasalazine | Folic Acid |
| Indomethacin | Iron |
| Antiviral Drugs | |
| Zidovudine | Vitamin B12, Copper, Zinc |
| Bronchodialators / Decongestants | |
| Theophylline | Vitamin B6 |
| Cardiovascular Drugs | |
| Ace Inhibitors | Zinc |
| Chlorthalidone | Zinc |
| Hydralazine-containing Vasodialators | Vitamin B6 |
| Loop Diuretics | Calcium, Potassium, Vitamin B6, Magnesium, Vitamin B1, and Zinc |
| Potassium-Sparing Diuretics | Folic Acid, Calcium |
| Thiazide Diuretics | Magnesium, Potassium, Zinc |
| Cardiac Glycosides | Calcium, Magnesium, Phosphorus, Thiamin |
| Cholesterol Lowering Agents | |
| Bile Acid Sequestrates (Colestid) | Vitamin A, Vitamin E, Vitamin D, Folic Acid, Vitamin B12, Iron |
| Electrolyte Replacement | |
| Potassium Chloride | Vitamin B12 |
| Female Hormones | |
| Estrogen Replacement Therapy | Vitamin B6 |
| Oral Contraceptives | Folic Acid, Vitamin B6,, Vitamin B12, Vitamin B2, Vitamin C, Magnesium, Zinc |
| Gout Medications | |
| Colchicine | Vitamin B12, Sodium, Potassium |
| Laxatives | |
| Mineral Oil | Vitamin A, Vitamin D, Vitamin E, Vitamin K, Calcium, Phosphorus |
| Bisacodyl | Potassium |
| Psychotherapeutic Drugs | |
| Tricyclic Antidepressants | Vitamin B2 |
| Phenothiazines | Vitamin B2 |
| Ulcer Medications | |
| H2 Blockers | Calcium, Vitamin D, Iron, Zinc, Vitamin B12, Folic Acid |
| Proton Pump Inhibitors | Vitamin B12 |
| Miscellaneous Drugs | |
| Methotrexate | Folic Acid |
| Penicillamine | Copper, Magnesium, Zinc |